NANO-DEVICES IN BIOTECHNOLOGY AND DRUG DELIVERY
Wing Kam Liu, Walter P. Murphy Professor, Northwestern University
Founding Chair of the ASME Nanotechnology Council
World Class Professor at SKKU
http://www.tam.northwestern.edu/wkl/liu.html , w-liu@northwestern.edu
The seminar opens with a lecture on modern uses of multiscale analysis, uncertainty quantification techniques, and validation experiments for the design of nanodevices in biotechnology and medicine. The 3D immersed finite element method for modeling the micro fluidic electrokinetic assembly of nano wires and filaments and bio-molecules will first be presented. This transformative bio-nanotechnology is being developed to enable drug delivery systems to achieve desired therapeutic effects and for the design and optimization of an electric field enabled nanotip DNA sensor. For the Nanodiamond-based drug delivery device we will discuss the multiscale analysis, quantum and molecular mechanics, immersed finite element and meshfree methods, uncertainty quantification, validation experiments. In addition, we will describe the mathematical formulation of pH control interactions among chemically functionalized nanodiamond, doxorubicin hydrochloride drugs and biocompatible parylene polymer. For the nanotip, we will discuss the underlying mechanics and physical parameters influencing the bio-sensing efficiency of the nanotip, such as the threshold of applied electric field, nano/microfluidics, bio-molecule deformation, and nanoscale Brownian motion. Through multiscale analysis, we will provide guidelines for nanodevice design, including fundamental mechanisms driving the system performance and optimization of distinct parameters for the high-sensitivity device throughput.
Vita: Dr. Wing Kam Liu , Walter P. Murphy Professor of Mechanical Engineering at Northwestern University, Founding Director of the NSF Summer Institute on Nano Mechanics and Materials, Founding Chairman of the prestigious ASME NanoEngineering Council, and Co-Director of the Northwestern University Predictive Science and Engineering Design Program, received his B.S. from the University of Illinois at Chicago; his M.S. and Ph.D. both from Caltech. He is a world leader in multiscale simulation-based engineering and science and has applied a spectrum of atomistic, quantum, and continuum strategies towards the understanding and design of nano-materials, biological processes, and recently the use of nano-materials for diagnostic and therapeutic applications. The impact of his research contributions is attested by the large number of citations to his work (over 9,000 according to Institute for Scientific Information (ISI) with an H-factor of 47; over 13,000 according to Google with an H-factor of 57). In 2001, he was cited by the ISI as “one of the most highly cited, influential researchers in Engineering, and an original member highly cited researchers database”. Selected honors include the 2009 ASME Dedicated Service Award, the Robert Henry Thurston Lecture Award, the Gustus L. Larson Memorial Award, the Dedicated Service Award, the Pi Tau Sigma Gold Medal and the Melville Medal, (all from ASME); the John von Neumann Medal and the Computational Structural Mechanics Award from the US Association of Computational Mechanics (USACM); and the Computational Mechanics Awards of the International Association of Computational Mechanics (IACM) and the Japanese Society of Mechanical Engineers. Liu chaired the ASME Applied Mechanics Division and is a past president of USACM. He is the editor of two International Journals and honorary editor of two journals and has been a consultant for more than 20 organizations. Liu has written three books; the Meshfree Particle Methods book sets the standard in the field, the Finite element book becomes a classic, and the Nano Mechanics and Materials book received a very favorable review by Nanotoday (Nov, 2006). Liu is a Fellow of ASME, ASCE, USACM, AAM, and IACM.